Molecular characterization of the hepatitis B virus in autochthonous and endogenous populations in the Western Brazilian Amazon

Molecular characterization of the hepatitis B virus in autochthonous and endogenous populations in the Western Brazilian Amazon

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INTRODUCTION: Hepatitis B virus (HBV) infection is a serious public health issue worldwide.Hepatitis B virus is classified into eight genotypes, varying from A to H, with distinct geographical distributions.In Brazil, the most frequent genotypes are A, D, and F.METHODS: This study animed aniflex complete aimed to characterize the HBV genotypes in cases of hepatitis B virus and hepatitis D virus (HDV) co-infections in an endemic area in the Western Brazilian Amazon.

We analyzed 86 serum samples reactive for HBsAg from indigenous and non-indigenous populations obtained from previous serological surveys.RESULTS: Of the 86 reactive serum samples, 39 were found to be HBV-DNA-positive by semi-nested PCR.The genotypes were established by sequencing the amplified S gene region.We obtained 20 sequences classified into three genotypes: A, D, and F.

Genotype A was the click here most frequent (60%), followed by D (35%) and F (5%).CONCLUSIONS: The distribution of the HBV genotypes reflected the pattern of historical occupation of the region.